| Product information | Protocols | References | Technical support | Reviews |
Product overview
| Product name | Cinnabarinic acid antibody |
| Synonyms | 2-amino- 3-oxo- 3H-phenoxazine-1,9-dicarboxylic acid antibody |
| Immunogen | Conjugated Cinnabarinic acid |
| Isotype | IgG1 k chain |
| Clone | clone 5C5-E10 |
| Specificity | When tested in competitive ELISA, the anti-Cinnabarinic acid antibody 5C5-E10 did not cross-react with its precursor, 3-OH-Anthranilic acid conjugates |
| Lot number | 140201 |
Storage
| Form | Liquid |
| Purity | Purified IgG |
| Concentration | 0,5 mg/ml |
| Storage | Store at +4°C for short term (1-2 months). Aliquot and store at -20°C for long term. Avoid repeated freeze / thaw cycles. |
| Material safety datasheet | Download MSDS |
Protocols
| Immunohistochemistry (IHC) | Dilute at 1:200-1:2000. Perform heat antigen retrieval (pH=6) before initiating IHC staining protocol on paraffin-embedded and frozen sections |
| Immunofluorescence (IF) | Dilute at 1:100-1:1000 on paraffin-embedded and frozen sections. Perform heat antigen retrieval and incubate with fluorescent secondary antibody conjugate. |
| Comments | Optimal working dilutions must be determined by the end-user |
| Restrictions | For research use only |
References
Antibody not yet cited. Submit an article and get a 10% discount.
Selected publications on Cinnabarinic acid:
- Fazio F, Zappulla C, Notartomaso S, Busceti C, Bessede A, Scarselli P, Vacca C, Gargaro M, Volpi C, Allegrucci M, Lionetto L, Simmaco M, Belladonna ML, Nicoletti F, Fallarino F. Cinnabarinicacid, an endogenous agonist of type-4 metabotropic glutamate receptor,suppresses experimental autoimmune encephalomyelitis in mice. Neuropharmacology. 2014 Feb 21. pii: S0028-3908(14)00075-6. doi: 10.1016/j.neuropharm.2014.02.011. [Epub ahead of print]
- Lowe MM, Mold JE, Kanwar B, Huang Y, Louie A, Pollastri MP, Wang C, Patel G, Franks DG, Schlezinger J, Sherr DH, Silverstone AE, Hahn ME, McCune JM. Identification of Cinnabarinic Acid as a Novel Endogenous Aryl Hydrocarbon Receptor Ligand That Drives IL-22 Production. PLoS One. 2014 Feb 3;9(2):e87877. doi: 10.1371/journal.pone.0087877. eCollection 2014.
- Fazio F, Lionetto L, Molinaro G, Bertrand HO, Acher F, Ngomba RT, Notartomaso S, Curini M, Rosati O, Scarselli P, Di Marco R, Battaglia G, Bruno V, Simmaco M, Pin JP, Nicoletti F, Goudet C. Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors. Mol Pharmacol. 2012 May;81(5):643-56. doi: 10.1124/mol.111.074765. Epub 2012 Feb 6.
- Fukuyama K, Tanahashi S, Hoshikawa M, Shinagawa R, Okada M. Zonisamide regulates basal ganglia transmission via astroglial kynurenine pathway. Neuropharmacology. 2014 Jan;76 Pt A:137-45. doi: 10.1016/j.neuropharm.2013.08.002. Epub 2013 Aug 22.
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