商品介绍
| Product information | Key steps | References | Technical support | Reviews |
Product overview
| Product name | Kynurenine/Tryptophan ratio ELISA pack |
| Description | Two enzyme immunoassays (ELISA) allowing the quantitative determination of L-Kynurenine to L-Tryptophan ratio in urine, plasma and serum samples. |
| Labels | CE |
| Format | 2 x 96-well plate |
| Samples | Plasma, serum, cell culture supernatant, (Urine) |
| Minimum sample volume | 20 µL |
| Cross specie-reactivity | React with all species |
| Standard range | KYN: 0/100 - 10000 ng/mlTRP: 2.5 - 250 µg/ml |
| Sensitivity | LoD KYN: < 47.5 ng/mlLoD TRP: < 1.2µg/ml |
| Specificity | No significant cross-reactivity was observed with L-Tryptophan and L-Kynurenine analogs. See product pages for L-Kynurenine ELISA and L-Tryptophan ELISA. |
| Storage | Store at 2-8°C for to 6 months. |
| Datasheets | Instructions for use - TRP kit, Instructions for use -KYN kit |
Key steps
| Sample collection & storage | Plasma/Serum: EDTA-, Heparin- or Citrate- samples stored at 2-8°C for up to 48h or -20°C for longer period (up to 6 months) |
| Sample preparation | KYN: Sample acylation (90 min)TRP: Sample precipitation (15 min) and derivatization (2h) |
| ELISA | Antisera overnight incubation, revelation and read steps (1h). |
| Detailed protocol | Instructions for use - TRP kit, Instructions for use - KYN kit |
References
Product citations :
- Agullo-Ortuno et al. Blood Predictive Biomarkers for Patients With Nonesmall-cell Lung Cancer Associated With Clinical Response to Nivolumab. Clin Lung Cancer. 2020 Jan
- Walker et al. Leucine competes with kynurenine for blood-to-brain transport and prevents lipopolysaccharide-induced depression-like behavior in mice. Mol Psychiatry. 2018 Jul 9.
- Ziklo et al. Dysbiosis of the Vaginal Microbiota and Higher Vaginal Kynurenine/Tryptophan Ratio Reveals an Association with Chlamydia trachomatis Genital Infections. Front Cell Infect Microbiol. 2018 Jan 18.
- Martiin-Hernandez et al. Chronic Mild Stress Alters Kynurenine Pathways Changing the Glutamate Neurotransmission in Frontal Cortex of Rats. Mol Neurobiol. 2018 May 3
- Toulmonde et al. Use of PD-1 Targeting, Macrophage Infiltration, and IDO Pathway Activation in Sarcomas. JAMA Oncol. 2018 Jan 1;4
Technical SupportSubmit a question
Asked2015-07-14
Answered2015-07-14
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